CircRNA—Protein Interactions in Muscle Development and Diseases

Circular RNA (circRNA) is a kind of novel endogenous noncoding formed through back-splicing mRNA precursor. The biogenesis, degradation, nucleus–cytoplasm transport, location, and even translation circRNA are controlled by RNA-binding proteins (RBPs). Therefore, circRNAs the chaperoned RBPs play critical roles in biological functions that significantly contribute to normal animal development disease. In this review, we systematically characterize possible molecular mechanism circRNA–protein interactions, summarize latest research on interactions muscle myocardial disease, discuss future application treating diseases. Finally, provide several valid prediction methods experimental verification approaches. Our review reveals significance their protein chaperones provides reference for further study field.